Genetic susceptibility to ischemic stroke
نویسندگان
چکیده
منابع مشابه
Genetic Predisposition to Ischemic Stroke
BACKGROUND AND PURPOSE The prediction of genetic predispositions to ischemic stroke (IS) may allow the identification of individuals at elevated risk and thereby prevent IS in clinical practice. Previously developed weighted multilocus genetic risk scores showed limited predictive ability for IS. Here, we investigated the predictive ability of a newer method, polygenic risk score (polyGRS), bas...
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Interrelationships between genetic and biochemical factors underlying ischemic stroke and ischemic heart disease are poorly understood. We: 1) undertook the most comprehensive meta-analysis of genetic polymorphisms in ischemic stroke to date; 2) compared genetic determinants of ischemic stroke with those of ischemic heart disease, and 3) compared effect sizes of gene-stroke associations with th...
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Introduction: stroke is the most important brain disease. Stroke leads to a reduction in bone density, altered calcium homeostasis, and an increase in hip fractures. Some recent studies show effects of vitamin D on stroke and vice versa. The purpose of this study was to determine of serum vitamin D levels in patients with acute stroke. Methods: In this cross-sectional study, we compared t...
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Introduction: Swallowing dysfunction complicates acute strokes in 25-32% of cases and directly affects patientschr('39') prognosis and recovery. Dysphagia complicates the course of acute strokes through its potential of the development of chest infection, nutritional problems, and dehydration. Dysphagia is also an independent predictor of respiratory morbidity and mortality in acute stroke. In...
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OBJECTIVE Increasing evidence suggests epidemiological and pathological links between Alzheimer's disease (AD) and Ischaemic Stroke (IS). We investigated the evidence that shared genetic factors underpin the two diseases. METHODS Using genome wide association study (GWAS) data from METASTROKE+ (15,916 IS cases and 68,826 controls) and IGAP (17,008 AD cases and 37,154 controls), we evaluated k...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2011
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2011.80